Using multidisciplinary approaches to understand important
questions in the organization and transduction mechanisms of
the olfactory system is our long-term research goal. In recent
years, we have focused on the role of gap junctions in coordination
and modulation of neuronal activity during olfactory sensation.
We use molecular biology, transgenics, immunohistochemistry,
biophysics and animal behaviour approaches to study the consequence
of gap junction deficiencies in the olfactory system in mouse
models. Our data suggest that gap junctional coupling may constitute
an important mechanism in maintaining olfactory sensitivity.
We are also exploring the functional role of gap junctions
in the organization and the formation of the olfactory system
during organogenesis. Our studies will provide insights to
fundamental questions in the olfactory system.
Further information on Chunbo Zhang's research.