Neurons do not work in isolation but rather operate together, within local interconnected circuits. Dr. MacLean's lab uses the latest technology in microscopy to allow the examination of the long standing questions of how information is encoded and stored in the neocortex, at the level of the functional neuronal circuit. Other techniques are limited to the examination of either large brain regions, missing the resolution needed to analyze the underlying mechanisms, or to single neurons, missing the activity of the circuit in which the neurons are embedded. Experiments at the circuit level are essential to answering these questions because studies in which single or even a few cells are monitored fundamentally miss the emergent properties of these circuits.
Further information on Jason MacLean's research.